Ontology highlight
ABSTRACT:
SUBMITTER: Niwa S
PROVIDER: S-EPMC5693321 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Niwa Shinsuke S Tao Li L Lu Sharon Y SY Liew Gerald M GM Feng Wei W Nachury Maxence V MV Shen Kang K
Current biology : CB 20170817 17
Axonal transport of synaptic vesicle precursors (SVPs) is essential for synapse development and function. The conserved ARF-like small GTPase ARL-8 is localized to SVPs and directly activates UNC-104/KIF1A, the axonal-transport kinesin for SVPs in C. elegans. It is not clear how ARL-8 is activated in this process. Here we show that part of the BLOC-1-related complex (BORC), previously shown to regulate lysosomal transport, is required to recruit and activate ARL-8 on SVPs. We found mutations in ...[more]