Ontology highlight
ABSTRACT:
SUBMITTER: Flores R
PROVIDER: S-EPMC3156137 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Flores Rafael R Hirota Yuki Y Armstrong Brian B Sawa Akira A Tomoda Toshifumi T
Neuroscience research 20110612 1
Disrupted-in-Schizophrenia 1 (DISC1) is a susceptibility gene for major mental illnesses, including bipolar disorder and schizophrenia. Although the roles of DISC1 in nervous system development and functions are increasingly recognized, pathophysiological mechanisms underlying a range of neuropsychiatric symptoms caused by DISC1 mutations remain unclear. Here we show that DISC1 enhances synaptic vesicle transport along microtubules. Knocking down DISC1 expression results in attenuated vesicle tr ...[more]