Unknown

Dataset Information

0

Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.


ABSTRACT: Effector T cells exhibiting features of either T helper 1 (Th1) or T follicular helper (Tfh) populations are essential to control experimental Plasmodium infection and are believed to be critical for resistance to clinical malaria. To determine whether Plasmodium-specific Th1- and Tfh-like effector cells generate memory populations that contribute to protection, we developed transgenic parasites that enable high-resolution study of anti-malarial memory CD4 T cells in experimental models. We found that populations of both Th1- and Tfh-like Plasmodium-specific memory CD4 T cells persist. Unexpectedly, Th1-like memory cells exhibit phenotypic and functional features of Tfh cells during recall and provide potent B cell help and protection following transfer, characteristics that are enhanced following ligation of the T cell co-stimulatory receptor OX40. Our findings delineate critical functional attributes of Plasmodium-specific memory CD4 T cells and identify a host-specific factor that can be targeted to improve resolution of acute malaria and provide durable, long-term protection against Plasmodium parasite re-exposure.

SUBMITTER: Zander RA 

PROVIDER: S-EPMC5693336 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Th1-like Plasmodium-Specific Memory CD4<sup>+</sup> T Cells Support Humoral Immunity.

Zander Ryan A RA   Vijay Rahul R   Pack Angela D AD   Guthmiller Jenna J JJ   Graham Amy C AC   Lindner Scott E SE   Vaughan Ashley M AM   Kappe Stefan H I SHI   Butler Noah S NS  

Cell reports 20171101 7


Effector T cells exhibiting features of either T helper 1 (Th1) or T follicular helper (Tfh) populations are essential to control experimental Plasmodium infection and are believed to be critical for resistance to clinical malaria. To determine whether Plasmodium-specific Th1- and Tfh-like effector cells generate memory populations that contribute to protection, we developed transgenic parasites that enable high-resolution study of anti-malarial memory CD4 T cells in experimental models. We foun  ...[more]

Similar Datasets

| S-EPMC7880450 | biostudies-literature
| S-EPMC9303986 | biostudies-literature
| S-EPMC153250 | biostudies-literature
| S-SCDT-10_15252-EMMM_202317713 | biostudies-other
| S-EPMC4019209 | biostudies-literature
| S-EPMC10701605 | biostudies-literature
| S-EPMC6345435 | biostudies-literature
| S-EPMC9148937 | biostudies-literature
2024-03-04 | GSE254265 | GEO
2024-01-15 | GSE253135 | GEO