Ontology highlight
ABSTRACT:
SUBMITTER: Leal Rojas IM
PROVIDER: S-EPMC5572390 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Leal Rojas Ingrid M IM Mok Wai-Hong WH Pearson Frances E FE Minoda Yoshihito Y Kenna Tony J TJ Barnard Ross T RT Radford Kristen J KJ
Frontiers in immunology 20170817
Dendritic cells (DC) initiate the differentiation of CD4<sup>+</sup> helper T cells into effector cells including Th1 and Th17 responses that play an important role in inflammation and autoimmune disease pathogenesis. In mice, Th1 and Th17 responses are regulated by different conventional (c) DC subsets, with cDC1 being the main producers of IL-12p70 and inducers of Th1 responses, while cDC2 produce IL-23 to promote Th17 responses. The role that human DC subsets play in memory CD4<sup>+</sup> T ...[more]