Ontology highlight
ABSTRACT:
SUBMITTER: Niessen S
PROVIDER: S-EPMC5693604 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Niessen Sherry S Dix Melissa M MM Barbas Sabrina S Potter Zachary E ZE Lu Shuyan S Brodsky Oleg O Planken Simon S Behenna Douglas D Almaden Chau C Gajiwala Ketan S KS Ryan Kevin K Ferre RoseAnn R Lazear Michael R MR Hayward Matthew M MM Kath John C JC Cravatt Benjamin F BF
Cell chemical biology 20170928 11
Patients with non-small cell lung cancers that have kinase-activating epidermal growth factor receptor (EGFR) mutations are highly responsive to first- and second-generation EGFR inhibitors. However, these patients often relapse due to a secondary, drug-resistant mutation in EGFR whereby the gatekeeper threonine is converted to methionine (T790M). Several third-generation EGFR inhibitors have been developed that irreversibly inactivate T790M-EGFR while sparing wild-type EGFR, thus reducing epith ...[more]