Ontology highlight
ABSTRACT:
SUBMITTER: Cho SJ
PROVIDER: S-EPMC7084700 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cho Soo Jung SJ Lee Mihye M Stout-Delgado Heather W HW Moon Jong-Seok JS
International journal of molecular sciences 20200228 5
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease. Chronic lung inflammation is linked to the pathogenesis of IPF. DROSHA, a class 2 ribonuclease III enzyme, has an important role in the biogenesis of microRNA (miRNA). The function of miRNAs has been identified in the regulation of the target gene or protein related to inflammatory responses via degradation of mRNA or inhibition of translation. The absent-in-melanoma-2 (AIM2) inflammasome is critical for inf ...[more]