Ontology highlight
ABSTRACT:
SUBMITTER: Stroud H
PROVIDER: S-EPMC5693680 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cell 20171019 5
In mammals, the environment plays a critical role in promoting the final steps in neuronal development during the early postnatal period. While epigenetic factors are thought to contribute to this process, the underlying molecular mechanisms remain poorly understood. Here, we show that in the brain during early life, the DNA methyltransferase DNMT3A transiently binds across transcribed regions of lowly expressed genes, and its binding specifies the pattern of DNA methylation at CA sequences (mCA ...[more]