Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Early-life gene expression in neurons modulates lasting epigenetic states.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Lambdavirus lambda

PROVIDER: GSE103214 | GEO | 2017/10/19

SECONDARY ACCESSION(S): PRJNA400549

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States.

Project description:In mammals, the environment plays a critical role in promoting the final steps in neuronal development during the early postnatal period. While epigenetic factors are thought to contribute to this process, the underlying molecular mechanisms remain poorly understood. Here, we show that in the brain during early life, the DNA methyltransferase DNMT3A transiently binds across transcribed regions of lowly expressed genes, and its binding specifies the pattern of DNA methylation at CA sequences (mCA) within these genes. We find that DNMT3A occupancy and mCA deposition within the transcribed regions of genes is negatively regulated by gene transcription and may be modified by early-life experience. Once deposited, mCA is bound by the methyl-DNA-binding protein MECP2 and functions in a rheostat-like manner to fine-tune the cell-type-specific transcription of genes that are critical for brain function.

| S-EPMC5693680 | biostudies-literature

Early-life gene expression in neurons modulates lasting epigenetic states [ChIP-Seq]

Project description:In mammals during the early postnatal period the environment plays a critical role in promoting the final steps in neuronal development. While epigenetic factors are thought to contribute to this process, the underlying molecular mechanisms remain poorly understood. Here we show that in the brain during early life the DNA methyltransferase DNMT3A transiently binds across transcribed regions of lowly expressed genes, and its binding specifies the pattern of DNA methylation at CA sequences (mCA) within these genes. We find that DNMT3A occupancy and mCA deposition within the transcribed regions of genes is negatively regulated by gene transcription and may be modified by early-life experience. Once deposited, mCA is bound by the methyl-DNA-binding protein MECP2 and functions in a rheostat-like manner to fine-tune the cell type-specific transcription of genes that are critical for brain function.

2017-10-19 | GSE104578 | GEO

Early-life gene expression in neurons modulates lasting epigenetic states. [Mnase-seq]

2017-10-19 | GSE104298 | GEO

Early-life gene expression in neurons modulates lasting epigenetic states. [Bisulfite-seq]

2017-10-19 | GSE103213 | GEO

Early-life gene expression in neurons modulates lasting epigenetic states. [RNA-Seq]

2017-10-19 | GSE103185 | GEO

Early-life gene expression in neurons modulates lasting epigenetic states. [RNA-seq 2]

2017-10-19 | GSE104325 | GEO

Early-life gene expression in neurons modulates lasting epigenetic states.

Project description:Early-life gene expression in neurons modulates lasting epigenetic states.

| PRJNA400549 | ENA