Ontology highlight
ABSTRACT:
SUBMITTER: Jain A
PROVIDER: S-EPMC5693794 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Jain A A Barrile R R van der Meer A D AD Mammoto A A Mammoto T T De Ceunynck K K Aisiku O O Otieno M A MA Louden C S CS Hamilton G A GA Flaumenhaft R R Ingber D E DE
Clinical pharmacology and therapeutics 20170714 2
Pulmonary thrombosis is a significant cause of patient mortality; however, there are no effective in vitro models of thrombi formation in human lung microvessels that could also assess therapeutics and toxicology of antithrombotic drugs. Here, we show that a microfluidic lung alveolus-on-a-chip lined by human primary alveolar epithelium interfaced with endothelium and cultured under flowing whole blood can be used to perform quantitative analysis of organ-level contributions to inflammation-indu ...[more]