Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5694690 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zhang Yingjie Y Yan Jin J Yao Tso-Pang TP
European journal of medicinal chemistry 20171010
There is increasing interest in discovering HDAC6 selective inhibitors as chemical probes to elucidate the biological functions of HDAC6 and ultimately as new therapeutic agents. Small-molecular fluorescent probes are widely used to detect target protein location and function, identify protein complex composition in biological processes of interest. In the present study, structural modification of the previously reported compound 4MS leads to two novel fluorescent HDAC inhibitors, 6a and 6b. Det ...[more]