Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4521150 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Wang Xia X Xu Tian-Ying TY Liu Xin-Zhu XZ Zhang Sai-Long SL Wang Pei P Li Zhi-Yong ZY Guan Yun-Feng YF Wang Shu-Na SN Dong Guo-Qiang GQ Zhuo Shu S Le Ying-Ying YY Sheng Chun-Quan CQ Miao Chao-Yu CY
Scientific reports 20150731
Nicotinamide phosphoribosyltransferase (NAMPT) is a promising antitumor target. Novel NAMPT inhibitors with diverse chemotypes are highly desirable for development of antitumor agents. Using high throughput screening system targeting NAMPT on a chemical library of 30000 small-molecules, we found a non-fluorescent compound F671-0003 and a fluorescent compound M049-0244 with excellent in vitro activity (IC50: 85 nM and 170 nM respectively) and anti-proliferative activity against HepG2 cells. These ...[more]