Ontology highlight
ABSTRACT:
SUBMITTER: Soya S
PROVIDER: S-EPMC5694764 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Soya Shingo S Takahashi Tohru M TM McHugh Thomas J TJ Maejima Takashi T Herlitze Stefan S Abe Manabu M Sakimura Kenji K Sakurai Takeshi T
Nature communications 20171120 1
Emotionally salient information activates orexin neurons in the lateral hypothalamus, leading to increase in sympathetic outflow and vigilance level. How this circuit alters animals' behavior remains unknown. Here we report that noradrenergic neurons in the locus coeruleus (NA<sup>LC</sup> neurons) projecting to the lateral amygdala (LA) receive synaptic input from orexin neurons. Pharmacogenetic/optogenetic silencing of this circuit as well as acute blockade of the orexin receptor-1 (OX1R) decr ...[more]