Ontology highlight
ABSTRACT:
SUBMITTER: Giustino TF
PROVIDER: S-EPMC6486780 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Giustino Thomas F TF Fitzgerald Paul J PJ Ressler Reed L RL Maren Stephen S
Proceedings of the National Academy of Sciences of the United States of America 20190410 17
The medial prefrontal cortex (mPFC) plays an essential role in regulating emotion, including inhibiting fear when danger has passed. The extinction of fear, however, is labile and a number of factors, including stress, cause extinguished fear to relapse. Here we show that fear relapse in rats limits single-unit activity among infralimbic (IL) neurons, which are critical for inhibiting fear responses, and facilitates activity in prelimbic (PL) neurons involved in fear expression. Pharmacogenetic ...[more]