Dataset Information

Risk of sudden cardiac death in relation to season-specific cold spells: a case-crossover study in Finland.

ABSTRACT:

Objective

To test a priori hypothesis of an association between season-specific cold spells and sudden cardiac death (SCD).

Methods

We conducted a case-crossover study of 3614 autopsy-verified cases of SCD in the Province of Oulu, Finland (1998-2011). Cold spell was statistically defined by applying an individual frequency distribution of daily temperatures at the home address during the hazard period (7 days preceding death) and 50 reference periods (same calendar days of other years) for each case using the home coordinates. Conditional logistic regression was applied to estimate ORs for the association between the occurrence of cold spells and the risk of SCD after controlling for temporal trends.

Results

The risk of SCD was associated with a preceding cold spell (OR 1.33; 95%?CI 1.00, 1.78). A greater number of cold days preceding death increased the risk of SCD approximately 19% per day (OR 1.19; 95%?CI 1.07 to 1.32). The association was strongest during autumn (OR 2.51; 95%?CI 1.27 to 4.96) and winter (OR 1.70; 95%?CI 1.13 to 2.55) and lowest during summer (OR 0.42; 95%?CI 0.15 to 1.18) and spring (OR 0.89; 95%?CI 0.45 to 1.79). The association was stronger for ischaemic (OR 1.55; 95%?CI 1.12 to 2.13) than for non-ischaemic SCD (OR 0.68; 95%?CI 0.32 to 1.45) verified by medicolegal autopsy.

Conclusions

Our results indicate that there is an association between cold spells and SCD, that this association is strongest during autumn, when the weather event is prolonged, and with cases suffering ischaemic SCD. These findings are subsumed with potential prevention via weather forecasting, medical advice and protective behaviour.

SUBMITTER: Ryti NRI

PROVIDER: S-EPMC5695410 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Publications

Risk of sudden cardiac death in relation to season-specific cold spells: a case-crossover study in Finland.

Ryti Niilo R I NRI Mäkikyrö Elina M S EMS Antikainen Harri H Hookana Eeva E Junttila M Juhani MJ Ikäheimo Tiina M TM Kortelainen Marja-Leena ML Huikuri Heikki V HV Jaakkola Jouni J K JJK

BMJ open 20171110 11

<h4>Objective</h4>To test <i>a priori</i> hypothesis of an association between season-specific cold spells and sudden cardiac death (SCD).<h4>Methods</h4>We conducted a case-crossover study of 3614 autopsy-verified cases of SCD in the Province of Oulu, Finland (1998-2011). Cold spell was statistically defined by applying an individual frequency distribution of daily temperatures at the home address during the hazard period (7 days preceding death) and 50 reference periods (same calendar days of ...[more]

PMID: 29127226

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Project description:BackgroundOut-of-hospital cardiac arrest (OHCA) is a time-critical and fatal medical emergency that has been linked to non-optimal temperatures. However, the future burden of OHCA due to non-optimal temperatures, heatwaves, and cold spells under climate change has not been well evaluated.MethodsWe conducted a time-stratified case-crossover study in 15 Northern Chinese cities throughout 2020 to estimate the exposure-response relationships of non-optimal temperatures, heatwaves, and cold spells with hourly OHCA onset in hot and cold seasons. We obtained future daily average temperatures by using 20 general circulation models under two greenhouse gas emission scenarios: one with certain emission control and the other with relaxed control. Lastly, we projected the change of OHCA burden under these two climate scenarios.FindingsWe analyzed a total of 29,671 OHCA patients and found that high temperatures and heatwaves as well as low temperatures and cold spells were all significantly associated with an increased risk of OHCA onset. Under the scenario of uncontrolled emissions, the attributable fraction (AF) of OHCA due to high temperatures and heatwaves would increase by 4.94% and 6.99% from the 2010s to 2090s, respectively. The AF due to low temperatures would decrease by 1.27% by the 2090s and the effects of cold spells were projected to be marginal after the 2050s. Under a medium emission control scenario, the upward trend of heat-related OHCA burden would become flat, and the decline in cold-related OHCA burden would also slow down.InterpretationOur study provides evidence of significant morbidity risk and burden of OHCA associated with global warming across Northern China. Our findings indicate that the increase in OHCA burden attributable to heat could not be offset by the decrements attributable to cold, emphasizing the importance of mitigation policies for limiting global warming and reducing the associated risks of OHCA onset.FundingNational Science & Technology Fundamental Resources Investigation Project (2018FY100600, 2018FY100602), National Key R&D Program of China (2020YFC1512700, 2020YFC1512705, 2020YFC1512703), Key R&D Program of Shandong Province (2021ZLGX02, 2021SFGC0503), Natural Science Foundation of Shandong Province (ZR2021MH231), Taishan Pandeng Scholar Program of Shandong Province (tspd20181220), the Interdisciplinary Young Researcher Groups Program of Shandong University (2020QNQT004), ECCM Program of Clinical Research Center of Shandong University (2021SDUCRCA001, 2021SDUCRCA002), foundation from Clinical Research Center of Shandong University (2020SDUCRCB003), National Natural Science Foundation of China (82272240).

Dataset Information

Risk of sudden cardiac death in relation to season-specific cold spells: a case-crossover study in Finland.

Objective

Methods

Results

Conclusions

Publications

Risk of sudden cardiac death in relation to season-specific cold spells: a case-crossover study in Finland.

Similar Datasets

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