Project description:Sudden unexplained death in childhood (SUDC) is death of a child over one year of age that is unexplained after review of clinical history, circumstances of death, and complete autopsy with ancillary testing. Multiple etiologies may cause SUDC, with parallels to sudden unexpected death in epilepsy (SUDEP) in SUDC with a history of febrile seizures, suggesting possible abnormalities in hippocampus and cortex. To identify molecular signaling pathways underlying SUDC, we performed label-free quantitative mass spectrometry on microdissected frontal cortex, hippocampal dentate gyrus (DG), and cornu ammonis (CA1-3) in SUDC (n=19) and pediatric control cases (n=19) with an explained cause of death.

2021-12-23 | MSV000088611 | MassIVE

The ablation of VEGFR-1 signaling promotes pressure overload–induced cardiac dysfunction and sudden death

Project description:Deletion of VEGFR-1 signaling appears not to have an effect on normal cardiac function but it inhibits the development of early compensatory LVH, which in turn leads to diastolic dysfunction associated with atrial dilatation and increased risk of sudden cardiac death

2021-04-20 | GSE162489 | GEO

Transcriptomic analysis of neuroinflammation and occult infection in sudden infant death syndrome

Project description:Antemortem infection is a risk factor for sudden infant death syndrome (SIDS) – the leading postneonatal cause of infant mortality in the developed world. Manifestations of infection and attendant inflammation, however, are not always apparent in clinical settings or by standard autopsy, thus enhanced resolution approaches are needed. Here we screened postmortem SIDS tissues and fluids for inflammatory markers and applied metagenomics and transcriptomics to a subset of cases to look for evidence of occult infection and inflammation.

2024-01-04 | GSE245891 | GEO

Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death

Project description:Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death

| PRJNA849237 | ENA