Ontology highlight
ABSTRACT:
SUBMITTER: Lee HC
PROVIDER: S-EPMC5695568 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Lee Hans C HC Wang Hua H Baladandayuthapani Veerabhadran V Lin Heather H He Jin J Jones Richard J RJ Kuiatse Isere I Gu Dongmin D Wang Zhiqiang Z Ma Wencai W Lim John J O'Brien Sean S Keats Jonathan J Yang Jing J Davis Richard E RE Orlowski Robert Z RZ
British journal of haematology 20170401 1
Dysregulation of MYC is frequently implicated in both early and late myeloma progression events, yet its therapeutic targeting has remained a challenge. Among key MYC downstream targets is ribosomal biogenesis, enabling increases in protein translational capacity necessary to support the growth and self-renewal programmes of malignant cells. We therefore explored the selective targeting of ribosomal biogenesis with the small molecule RNA polymerase (pol) I inhibitor CX-5461 in myeloma. CX-5461 i ...[more]