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Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Isoform Epsilon Signaling Mediates Glycolytic Metabolites for Vascular Repair.

ABSTRACT:

Aims

Hemodynamic shear stress participates in maintaining vascular redox status. Elucidating flow-mediated endothelial metabolites enables us to discover metabolic biomarkers and therapeutic targets. We posited that flow-responsive vascular endothelial growth factor receptor (VEGFR)-protein kinase C isoform epsilon (PKC?)-6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) signaling modulates glycolytic metabolites for vascular repair.

Results

Bidirectional oscillatory flow (oscillatory shear stress [OSS]: 0.1?±?3 dyne·cm^-2 at 1?Hz) upregulated VEGFR-dependent PKC? expression to a greater degree than did unidirectional pulsatile flow (pulsatile shear stress [PSS]: 23?±?8 dyne·cm^-2 at 1?Hz) in human aortic endothelial cells (p?

SUBMITTER: Baek KI

PROVIDER: S-EPMC5695747 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Isoform Epsilon Signaling Mediates Glycolytic Metabolites for Vascular Repair.

Baek Kyung In KI Li Rongsong R Jen Nelson N Choi Howard H Kaboodrangi Amir A Ping Peipei P Liem David D Beebe Tyler T Hsiai Tzung K TK

Antioxidants & redox signaling 20170921 1

<h4>Aims</h4>Hemodynamic shear stress participates in maintaining vascular redox status. Elucidating flow-mediated endothelial metabolites enables us to discover metabolic biomarkers and therapeutic targets. We posited that flow-responsive vascular endothelial growth factor receptor (VEGFR)-protein kinase C isoform epsilon (PKCɛ)-6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) signaling modulates glycolytic metabolites for vascular repair.<h4>Results</h4>Bidirectional oscillatory ...[more]

PMID: 28762754

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