Ontology highlight
ABSTRACT:
SUBMITTER: Zhang YP
PROVIDER: S-EPMC5678172 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Zhang Yun-Peng YP Huang Yi-Tao YT Huang Tse-Shun TS Pang Wei W Zhu Juan-Juan JJ Liu Yue-Feng YF Tang Run-Ze RZ Zhao Chuan-Rong CR Yao Wei-Juan WJ Li Yi-Shuan YS Chien Shu S Zhou Jing J
Scientific reports 20171108 1
The earliest atherosclerotic lesions preferentially develop in arterial regions experienced disturbed blood flow, which induces endothelial expression of pro-atherogenic genes and the subsequent endothelial dysfunction. Our previous study has demonstrated an up-regulation of DNA methyltransferase 1 (DNMT1) and a global hypermethylation in vascular endothelium subjected to disturbed flow. Here, we determined that DNMT1-specific inhibition in arterial wall ameliorates the disturbed flow-induced at ...[more]