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Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona.

ABSTRACT: Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages.

SUBMITTER: Saha K

PROVIDER: S-EPMC5696791 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona.

Saha Krishnendu K Rahimi Mehran M Yazdani Mahdieh M Kim Sung Tae ST Moyano Daniel F DF Hou Singyuk S Das Ridhha R Mout Rubul R Rezaee Farhad F Mahmoudi Morteza M Rotello Vincent M VM

ACS nano 20160411 4

Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, th ...[more]

PMID: 27040442

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