Ontology highlight
ABSTRACT:
SUBMITTER: Saha K
PROVIDER: S-EPMC5696791 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Saha Krishnendu K Rahimi Mehran M Yazdani Mahdieh M Kim Sung Tae ST Moyano Daniel F DF Hou Singyuk S Das Ridhha R Mout Rubul R Rezaee Farhad F Mahmoudi Morteza M Rotello Vincent M VM
ACS nano 20160411 4
Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, th ...[more]