Ontology highlight
ABSTRACT:
SUBMITTER: Zhu H
PROVIDER: S-EPMC5698429 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171122 1
Choline acetyltransferase neurons in the vertical diagonal band of Broca (vChATs) degenerate in the early stage of Alzheimer's disease (AD). Here, we report that vChATs directly innervate newly generated immature neurons (NGIs) in the dorsal hippocampus (dNGIs) of adult mice and regulate both the dNGIs survival and spatial pattern separation. In a mouse model that exhibits amyloid-β plaques similar to AD patients, cholinergic synaptic transmission, dNGI survival and spatial pattern separation ar ...[more]