Ontology highlight
ABSTRACT:
SUBMITTER: Naganuma F
PROVIDER: S-EPMC5698467 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Naganuma Fumito F Nakamura Tadaho T Yoshikawa Takeo T Iida Tomomitsu T Miura Yamato Y Kárpáti Anikó A Matsuzawa Takuro T Yanai Atushi A Mogi Asuka A Mochizuki Takatoshi T Okamura Nobuyuki N Yanai Kazuhiko K
Scientific reports 20171121 1
Histamine is a neurotransmitter that regulates diverse physiological functions including the sleep-wake cycle. Recent studies have reported that histaminergic dysfunction in the brain is associated with neuropsychiatric disorders. Histamine N-methyltransferase (HNMT) is an enzyme expressed in the central nervous system that specifically metabolises histamine; yet, the exact physiological roles of HNMT are unknown. Accordingly, we phenotyped Hnmt knockout mice (KO) to determine the relevance of H ...[more]