Ultrastructural evidence for synaptic scaling across the wake/sleep cycle.
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ABSTRACT:
SUBMITTER: de Vivo L
PROVIDER: S-EPMC5313037 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle.
de Vivo Luisa L Bellesi Michele M Marshall William W Bushong Eric A EA Ellisman Mark H MH Tononi Giulio G Cirelli Chiara C
Science (New York, N.Y.) 20170201 6324
It is assumed that synaptic strengthening and weakening balance throughout learning to avoid runaway potentiation and memory interference. However, energetic and informational considerations suggest that potentiation should occur primarily during wake, when animals learn, and depression should occur during sleep. We measured 6920 synapses in mouse motor and sensory cortices using three-dimensional electron microscopy. The axon-spine interface (ASI) decreased ~18% after sleep compared with wake. ...[more]
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