Electrical stimulation improved cognitive deficits associated with traumatic brain injury in rats.

ABSTRACT:

Introduction

Cognitive deficits associated with traumatic brain injury (TBI) reduce patient quality of life. However, to date, there have been no effective treatments for TBI-associated cognitive deficits. In this study, we aimed to determine whether electrical stimulation (ES) improves cognitive deficits in TBI rats.

Methods

Rats were randomly divided into three groups: the Sham control group, electrical stimulation group (ES group), and No electrical stimulation control group (N-ES group). Following fluid percussion injury, the rats in the ES group received ES treatment for 3 weeks. Potent cognitive function-relevant factors, including the escape latency, time percentage in the goal quadrant, and numbers of CD34⁺ cells, von Willebrand Factor⁺ (vWF

SUBMITTER: Zheng ZT 

PROVIDER: S-EPMC5698854 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature