Ontology highlight
ABSTRACT:
SUBMITTER: Ershov P
PROVIDER: S-EPMC5699483 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Ershov Pavel P Mezentsev Yuri Y Gilep Andrey A Usanov Sergey S Buneeva Olga O Medvedev Alexei A Ivanov Alexis A
Protein science : a publication of the Protein Society 20171009 12
Isatin (indol-2,3-dione) is an endogenous non-peptide regulator exhibiting a wide range of biological and pharmacological activities, which are poorly characterized in terms of their molecular mechanisms. Identification of many isatin-binding proteins in the mammalian brain and liver suggests that isatin may influence their functions. We have hypothesized that besides direct action on particular protein targets, isatin can act as a regulator of protein-protein interactions (PPIs). In this surfac ...[more]