Ontology highlight
ABSTRACT:
SUBMITTER: Do HT
PROVIDER: S-EPMC5699933 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20171101 22
Inhibition of neuronal nitric oxide synthase (nNOS) is a promising therapeutic approach to treat neurodegenerative diseases. Recently, we have achieved considerable progress in improving the potency and isoform selectivity of human nNOS inhibitors bearing a 2-aminopyridine scaffold. However, these inhibitors still suffered from too low cell membrane permeability to enter into CNS drug development. We report herein our studies to improve permeability of nNOS inhibitors as measured by both PAMPA-B ...[more]