Ontology highlight
ABSTRACT:
SUBMITTER: Sato M
PROVIDER: S-EPMC5700171 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20171122 1
The production costs for monoclonal antibodies (MAbs) utilized in medical diagnostic kits are inevitably high because the MAbs are mostly obtained from hybridoma cell culture. Here, we report the development and validation of a novel affinity silk protein produced by transgenic silkworm technology as a possible alternative diagnostic tool for cancers. We generated a transgenic silkworm expressing a cDNA construct containing fibroin L-chain fused to a single-chain variable fragment (scFv) derived ...[more]