Association between borderline dysnatremia and mortality insight into a new data mining approach.

ABSTRACT:

Background

Even small variations of serum sodium concentration may be associated with mortality. Our objective was to confirm the impact of borderline dysnatremia for patients admitted to hospital on in-hospital mortality using real life care data from our electronic health record (EHR) and a phenome-wide association analysis (PheWAS).

Methods

Retrospective observational study based on patient data admitted to Hôpital Européen George Pompidou, between 01/01/2008 and 31/06/2014; including 45,834 patients with serum sodium determinations on admission. We analyzed the association between dysnatremia and in-hospital mortality, using a multivariate logistic regression model to adjust for classical potential confounders. We performed a PheWAS to identify new potential confounders.

SUBMITTER: Girardeau Y 

PROVIDER: S-EPMC5700671 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature