Ontology highlight
ABSTRACT:
SUBMITTER: Liang H
PROVIDER: S-EPMC5701019 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Liang Hua H Deng Liufu L Hou Yuzhu Y Meng Xiangjiao X Huang Xiaona X Rao Enyu E Zheng Wenxin W Mauceri Helena H Mack Matthias M Xu Meng M Fu Yang-Xin YX Weichselbaum Ralph R RR
Nature communications 20171123 1
Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important role. However, radioresistance in irradiated tumors can also develop, resulting in relapse. Here we report a mechanism by which extrinsic resistance develops after local ablative radiation that relies on the immunosuppressive action of STING. The STING/type I interferon pathway enhances suppressive inflammation in tumors by recruiting myeloid cells in part via the CCR2 pathway. Germ-line knockou ...[more]