Ontology highlight
ABSTRACT:
SUBMITTER: Konuma T
PROVIDER: S-EPMC5701133 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Konuma Tsuyoshi T Yu Di D Zhao Chengcheng C Ju Ying Y Sharma Rajal R Ren Chunyan C Zhang Qiang Q Zhou Ming-Ming MM Zeng Lei L
Scientific reports 20171124 1
Jumonji domain-containing protein 6 (JMJD6) is a member of the Jumonji C family of Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases. It possesses unique bi-functional oxygenase activities, acting as both an arginine demethylase and a lysyl-hydroxylase. JMJD6 has been reported to be over-expressed in oral, breast, lung, and colon cancers and plays important roles in regulation of transcription through interactions with transcription regulator BRD4, histones, U2AF65, Luc7L3, and SRSF11. Here, ...[more]