Ontology highlight
ABSTRACT:
SUBMITTER: Lin YJ
PROVIDER: S-EPMC2590908 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Lin Yi-Jan YJ Umehara Takashi T Inoue Makoto M Saito Kohei K Kigawa Takanori T Jang Moon-Kyoo MK Ozato Keiko K Yokoyama Shigeyuki S Padmanabhan Balasundaram B Güntert Peter P
Protein science : a publication of the Protein Society 20080924 12
BRD4, which is a member of the BET (bromodomains and extraterminal) protein family, interacts preferentially with acetylated chromatin and possesses multiple cellular functions in meiosis, embryonic development, the cell cycle, and transcription. BRD4 and its family members contain two bromodomains known to bind acetylated lysine, and a conserved ET domain whose function is unclear. Here we show the solution structure of the ET domain of mouse BRD4, which provides the first three-dimensional str ...[more]