Ontology highlight
ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC5701193 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171124 1
Maturation of HIV-1 particles encompasses a complex morphological transformation of Gag via an orchestrated series of proteolytic cleavage events. A longstanding question concerns the structure of the C-terminal region of CA and the peptide SP1 (CA-SP1), which represents an intermediate during maturation of the HIV-1 virus. By integrating NMR, cryo-EM, and molecular dynamics simulations, we show that in CA-SP1 tubes assembled in vitro, which represent the features of an intermediate assembly sta ...[more]