Ontology highlight
ABSTRACT:
SUBMITTER: Casson J
PROVIDER: S-EPMC5702047 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Casson Joseph J McKenna Michael M Haßdenteufel Sarah S Aviram Naama N Zimmerman Richard R High Stephen S
Journal of cell science 20171011 22
Tail-anchored (TA) proteins are transmembrane proteins with a single C-terminal transmembrane domain, which functions as both their subcellular targeting signal and membrane anchor. We show that knockout of TRC40 in cultured human cells has a relatively minor effect on endogenous TA proteins, despite their apparent reliance on this pathway <i>in vitro</i> These findings support recent evidence that the canonical TRC40 pathway is not essential for TA protein biogenesis <i>in vivo</i> We therefore ...[more]