Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC5703269 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Xu Xuehua X Wen Xi X Veltman Douwe M DM Keizer-Gunnink Ineke I Pots Henderikus H Kortholt Arjan A Jin Tian T
Proceedings of the National Academy of Sciences of the United States of America 20171106 47
Eukaryotic cells chemotax in a wide range of chemoattractant concentration gradients, and thus need inhibitory processes that terminate cell responses to reach adaptation while maintaining sensitivity to higher-concentration stimuli. However, the molecular mechanisms underlying inhibitory processes are still poorly understood. Here, we reveal a locally controlled inhibitory process in a GPCR-mediated signaling network for chemotaxis in <i>Dictyostelium discoideum</i> We identified a negative reg ...[more]