Ontology highlight
ABSTRACT:
SUBMITTER: Harmon TS
PROVIDER: S-EPMC5703641 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Harmon Tyler S TS Holehouse Alex S AS Rosen Michael K MK Pappu Rohit V RV
eLife 20171101
Phase transitions of linear multivalent proteins control the reversible formation of many intracellular membraneless bodies. Specific non-covalent crosslinks involving domains/motifs lead to system-spanning networks referred to as gels. Gelation transitions can occur with or without phase separation. In gelation driven by phase separation multivalent proteins and their ligands condense into dense droplets, and gels form within droplets. System spanning networks can also form without a condensati ...[more]