Ontology highlight
ABSTRACT:
SUBMITTER: Chim N
PROVIDER: S-EPMC5703726 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Chim Nicholas N Shi Changhua C Sau Sujay P SP Nikoomanzar Ali A Chaput John C JC
Nature communications 20171127 1
Darwinian evolution experiments carried out on xeno-nucleic acid (XNA) polymers require engineered polymerases that can faithfully and efficiently copy genetic information back and forth between DNA and XNA. However, current XNA polymerases function with inferior activity relative to their natural counterparts. Here, we report five X-ray crystal structures that illustrate the pathway by which α-(L)-threofuranosyl nucleic acid (TNA) triphosphates are selected and extended in a template-dependent ...[more]