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Switching between Multiple Codes of SNARC-Like Associations: Two Conceptual Replication Attempts with Anodal tDCS in Sham-Controlled Cross-Over Design.

ABSTRACT: In societies with left-to-right reading direction, left-side vs. right-side behavioral decisions are faster for relatively small vs. large number magnitudes, and vice versa, a phenomenon termed Spatial-Numerical Associations of Response Codes (SNARC) effect. But also for non-numerical sequential items, SNARC-like effects were observed, suggesting a common neurocognitive mechanism based on the ordinal structures of both numbers and sequences. Modulation of prefrontal networks that are involved in providing spatial associations during cognitive behavior can contribute to elaborate their neuropsychological theoretical foundations. With transcranial direct current stimulation (tDCS) directed to the left prefrontal cortex, we recently showed that (i) cathodal tDCS can block the emergence of spatial-numerical associations and that (ii) anodal tDCS can reverse spatial associations of sequential order, most likely based on markedness correspondence. Two conceptual replication attempts of the latter reversal of space-order associations are presented in the current sham-controlled experiment, using either weekdays (Monday-Friday) or month names (January-December) as stimuli in the temporal order classification task. In addition, to control for possible influences of notation, number stimuli were presented as written German names (One-Five). We report on a successful modulation of spatial-numerical associations of response codes (SNARC) effects with month stimuli induced by anodal tDCS, but failed to observe the same reversal of SNARC effects for weekday stimuli. The former stimulation effect was orthogonal to the small anodal tDCS effect on written number words, which replicates the dissociation of SNARC effects for numbers vs. non-numerical sequences. Moreover, this result reinforces the hypothesis that the ordinal item and task structure was the source of dissociation (as opposed to verbal presentation). We suggest that the diverging results can be explained by the markedness correspondence account of spatial associations in a multiple coding framework. Left-hemispheric prefrontal excitation from anodal tDCS renders verbal markedness relatively more dominant, but this effect is not absolute. We discuss task contagion, study design, and individual differences in performance measures or tDCS response as possible contributors to systematic variation of the weights of multiple coding parameters for spatial-numerical associations.

SUBMITTER: Schroeder PA

PROVIDER: S-EPMC5703834 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Switching between Multiple Codes of SNARC-Like Associations: Two Conceptual Replication Attempts with Anodal tDCS in Sham-Controlled Cross-Over Design.

Schroeder Philipp A PA Nuerk Hans-Christoph HC Plewnia Christian C

Frontiers in neuroscience 20171123

In societies with left-to-right reading direction, left-side vs. right-side behavioral decisions are faster for relatively small vs. large number magnitudes, and vice versa, a phenomenon termed Spatial-Numerical Associations of Response Codes (SNARC) effect. But also for non-numerical sequential items, SNARC-like effects were observed, suggesting a common neurocognitive mechanism based on the ordinal structures of both numbers and sequences. Modulation of prefrontal networks that are involved in ...[more]

PMID: 29217996

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Project description:BackgroundSince a stroke can impair bimanual activities, enhancing bimanual cooperation through motor skill learning may improve neurorehabilitation. Therefore, robotics and neuromodulation with transcranial direct current stimulation (tDCS) are promising approaches. To date, tDCS has failed to enhance bimanual motor control after stroke possibly because it was not integrating the hypothesis that the undamaged hemisphere becomes the major poststroke hub for bimanual control.ObjectiveWe tested the following hypotheses: (I) In patients with chronic hemiparetic stroke training on a robotic device, anodal tDCS applied over the primary motor cortex of the undamaged hemisphere enhances bimanual motor skill learning compared to sham tDCS. (II) The severity of impairment correlates with the effect of tDCS on bimanual motor skill learning. (III) Bimanual motor skill learning is less efficient in patients than in healthy individuals (HI).MethodsA total of 17 patients with chronic hemiparetic stroke and 7 healthy individuals learned a complex bimanual cooperation skill on the REAplan® neurorehabilitation robot. The bimanual speed/accuracy trade-off (biSAT), bimanual coordination (biCo), and bimanual force (biFOP) scores were computed for each performance. In patients, real/sham tDCS was applied in a crossover, randomized, double-blind approach.ResultsCompared to sham, real tDCS did not enhance bimanual motor skill learning, retention, or generalization in patients, and no correlation with impairment was noted. The healthy individuals performed better than patients on bimanual motor skill learning, but generalization was similar in both groups.ConclusionA short motor skill learning session with a robotic device resulted in the retention and generalization of a complex skill involving bimanual cooperation. The tDCS strategy that would best enhance bimanual motor skill learning after stroke remains unknown.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT02308852, identifier: NCT02308852.

Project description:Anodal transcranial direct current stimulation (tDCS), applied over the left dorsolateral prefrontal cortex (lDLPFC), can produce significant effects on working memory (WM) performance and associated neurophysiological activity. However, results from previous studies are inconsistent and occasionally contradictory. This inconsistency may be attributed to methodological and individual differences during experiments. This study therefore investigated two hypotheses: (1) A multichannel-optimized montage was expected to be more effective than a classical bipolar montage, because of increased focality. (2) The subjects were expected to benefit differently from the stimulation depending on their initial task performance. In a sham-controlled crossover study, 24 healthy participants received bipolar, multichannel, and sham stimulation for 20 min in randomized order, targeting the lDLPFC while performing a 2-back WM task. After stimulation, electroencephalography (EEG) was recorded at rest and during 2-back and nontarget continuous performance task (CPT) performance. Bipolar and multichannel stimulations were both well tolerated and effectively blinded. We found no effect of stimulation on behavioral performance or neuronal oscillations comparing the classical bipolar or multichannel montage with sham stimulation. We did, however, find an interaction between stimulation and initial task performance. For multichannel stimulation, initially low-performing participants tended to improve their WM performance while initially high-performing participants tended to worsen their performance compared to sham stimulation. Both tDCS montages induced changes in neural oscillatory power, which correlated with baseline performance. The worse the participants' initial WM performance was, the more task-related theta power was induced by multichannel and bipolar stimulation. The same effect was observed for alpha power in the nontarget task following multichannel stimulation. Notably, we were not able to show a superiority of multichannel stimulation compared to bipolar stimulation. Still, comparing both montages with sham stimulation, multichannel stimulation led to stronger effects than bipolar stimulation. The current study highlights the importance of investigating different parameters with potential influence on tDCS effects in combination. Our results demonstrate how individual differences in cognitive performance and electrode montages influence effects of tDCS on neuropsychological performance. These findings support the idea of an individualized and optimized stimulation setting, potentially leading to increased tDCS effects.

Dataset Information

Switching between Multiple Codes of SNARC-Like Associations: Two Conceptual Replication Attempts with Anodal tDCS in Sham-Controlled Cross-Over Design.

Publications

Switching between Multiple Codes of SNARC-Like Associations: Two Conceptual Replication Attempts with Anodal tDCS in Sham-Controlled Cross-Over Design.

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