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Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression.


ABSTRACT: Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial-mesenchymal transition. Here, we demonstrate that VGF is epigenetically modified in non-small cell lung cancer tissues compared to corresponding tumor-free lung tissues from the same donors by using methylome bead chip analyses. These epigenetic modifications trigger an increased transcription of the VGF gene within the tumors, which then leads to an increased expression of the protein, facilitating epithelial-mesenchymal transition, and the resistance to kinase inhibitors. These results should be taken into account in the design of novel therapeutic and diagnostic approaches.

SUBMITTER: Marwitz S 

PROVIDER: S-EPMC5704452 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression.

Marwitz Sebastian S   Heinbockel Lena L   Scheufele Swetlana S   Nitschkowski Dörte D   Kugler Christian C   Perner Sven S   Reck Martin M   Ammerpohl Ole O   Goldmann Torsten T  

Clinical epigenetics 20171128


Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial-mesenchymal transition. Here, we demonstrate that VGF is epigenetically modified in non-small cell lung cancer tissues compared to corresponding tumor-free lung tissues from the same donors by using methylome bead chip analyses. These epigenetic modifications trigger an increased tra  ...[more]

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