Ontology highlight
ABSTRACT:
SUBMITTER: Marwitz S
PROVIDER: S-EPMC5704452 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Marwitz Sebastian S Heinbockel Lena L Scheufele Swetlana S Nitschkowski Dörte D Kugler Christian C Perner Sven S Reck Martin M Ammerpohl Ole O Goldmann Torsten T
Clinical epigenetics 20171128
Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial-mesenchymal transition. Here, we demonstrate that VGF is epigenetically modified in non-small cell lung cancer tissues compared to corresponding tumor-free lung tissues from the same donors by using methylome bead chip analyses. These epigenetic modifications trigger an increased tra ...[more]