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Low flow extracorporeal CO2 removal in ARDS patients: a prospective short-term crossover pilot study.


ABSTRACT: Lung protective mechanical ventilation (MV) is the corner stone of therapy for ARDS. However, its use may be limited by respiratory acidosis. This study explored feasibility of, effectiveness and safety of low flow extracorporeal CO2 removal (ECCO2R).This was a prospective pilot study, using the Abylcap® (Bellco) ECCO2R, with crossover off-on-off design (2-h blocks) under stable MV settings, and follow up till end of ECCO2R. Primary endpoint for effectiveness was a 20% reduction of PaCO2 after the first 2-h. Adverse events (AE) were recorded prospectively. We included 10 ARDS patients on MV, with PaO2/FiO2?

SUBMITTER: Peperstraete H 

PROVIDER: S-EPMC5704518 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Low flow extracorporeal CO<sub>2</sub> removal in ARDS patients: a prospective short-term crossover pilot study.

Peperstraete Harlinde H   Eloot Sunny S   Depuydt Pieter P   De Somer Filip F   Roosens Carl C   Hoste Eric E  

BMC anesthesiology 20171128 1


<h4>Background</h4>Lung protective mechanical ventilation (MV) is the corner stone of therapy for ARDS. However, its use may be limited by respiratory acidosis. This study explored feasibility of, effectiveness and safety of low flow extracorporeal CO<sub>2</sub> removal (ECCO<sub>2</sub>R).<h4>Methods</h4>This was a prospective pilot study, using the Abylcap® (Bellco) ECCO<sub>2</sub>R, with crossover off-on-off design (2-h blocks) under stable MV settings, and follow up till end of ECCO<sub>2<  ...[more]

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