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Feasibility and safety of low-flow extracorporeal CO2 removal managed with a renal replacement platform to enhance lung-protective ventilation of patients with mild-to-moderate ARDS.


ABSTRACT: BACKGROUND:Extracorporeal carbon-dioxide removal (ECCO2R) might allow ultraprotective mechanical ventilation with lower tidal volume (VT) (?20% from its initial value. Ventilation parameters (VT, respiratory rate, PEEP), respiratory system compliance, Pplat and driving pressure, arterial blood gases, and ECCO2R-system operational characteristics were collected during at least 24 h of very low tidal volume ventilation. Complications, day-28 mortality, need for adjuvant therapies, and data on weaning off ECCO2R and mechanical ventilation were also recorded. RESULTS:While VT was reduced from 6 to 4 ml/kg and Pplat kept

SUBMITTER: Schmidt M 

PROVIDER: S-EPMC5944133 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Feasibility and safety of low-flow extracorporeal CO<sub>2</sub> removal managed with a renal replacement platform to enhance lung-protective ventilation of patients with mild-to-moderate ARDS.

Schmidt Matthieu M   Jaber Samir S   Zogheib Elie E   Godet Thomas T   Capellier Gilles G   Combes Alain A  

Critical care (London, England) 20180510 1


<h4>Background</h4>Extracorporeal carbon-dioxide removal (ECCO<sub>2</sub>R) might allow ultraprotective mechanical ventilation with lower tidal volume (VT) (< 6 ml/kg predicted body weight), plateau pressure (P<sub>plat</sub>) (< 30 cmH<sub>2</sub>O), and driving pressure to limit ventilator-induced lung injury. This study was undertaken to assess the feasibility and safety of ECCO<sub>2</sub>R managed with a renal replacement therapy (RRT) platform to enable very low tidal volume ventilation o  ...[more]

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