Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases.
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ABSTRACT:
SUBMITTER: Ananthakrishnan AN
PROVIDER: S-EPMC5705050 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases.
Ananthakrishnan Ashwin N AN Luo Chengwei C Yajnik Vijay V Khalili Hamed H Garber John J JJ Stevens Betsy W BW Cleland Thomas T Xavier Ramnik J RJ
Cell host & microbe 20170501 5
The gut microbiome plays a central role in inflammatory bowel diseases (IBDs) pathogenesis and propagation. To determine whether the gut microbiome may predict responses to IBD therapy, we conducted a prospective study with Crohn's disease (CD) or ulcerative colitis (UC) patients initiating anti-integrin therapy (vedolizumab). Disease activity and stool metagenomes at baseline, and weeks 14, 30, and 54 after therapy initiation were assessed. Community α-diversity was significantly higher, and Ro ...[more]
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