Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis.
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ABSTRACT:
SUBMITTER: Casimiro MC
PROVIDER: S-EPMC5705201 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis.
Casimiro Mathew C MC Di Sante Gabriele G Di Rocco Agnese A Loro Emanuele E Pupo Claudia C Pestell Timothy G TG Bisetto Sara S Velasco-Velázquez Marco A MA Jiao Xuanmao X Li Zhiping Z Kusminski Christine M CM Seifert Erin L EL Wang Chenguang C Ly Daniel D Zheng Bin B Shen Che-Hung CH Scherer Philipp E PE Pestell Richard G RG
Cancer research 20170518 13
Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by modulating the activation of AMPK. In cell models of human breast cancer or in a cyclin D1-deficient model, we observed a cyclin D1-mediated reduction in AMPK activation. Mechanistic investigations showed that cyclin D1 inhibited mitochondrial f ...[more]
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