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Cytotoxic and Antibacterial Compounds from the Coral-Derived Fungus Aspergillus tritici SP2-8-1.


ABSTRACT: Three novel compounds, 4-methyl-candidusin A (1), aspetritone A (2) and aspetritone B (3), were obtained from the culture of a coral-derived fungus Aspergillus tritici SP2-8-1, together with fifteen known compounds (4-18). Their structures, including absolute configurations, were assigned based on NMR, MS, and time-dependent density functional theory (TD-DFT) ECD calculations. Compounds 2 and 5 exhibited better activities against methicillin-resistant strains of S. aureus (MRSA) ATCC 43300 and MRSA CGMCC 1.12409 than the positive control chloramphenicol. Compound 5 displayed stronger anti-MRSA and lower cytotoxic activities than 2, and showed stronger antibacterial activities against strains of Vibrio vulnificus, Vibrio rotiferianus, and Vibrio campbellii than the other compounds. Compounds 2 and 10 exhibited significantly stronger cytotoxic activities against human cancer cell lines HeLa, A549, and Hep G2 than the other compounds. Preliminary structure-activity relationship studies indicated that prenylation of terphenyllin or candidusin and the tetrahydrobenzene moiety in anthraquinone derivatives may influence their bioactivity.

SUBMITTER: Wang W 

PROVIDER: S-EPMC5706038 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Cytotoxic and Antibacterial Compounds from the Coral-Derived Fungus Aspergillus tritici SP2-8-1.

Wang Weiyi W   Liao Yanyan Y   Tang Chao C   Huang Xiaomei X   Luo Zhuhua Z   Chen Jianming J   Cai Peng P  

Marine drugs 20171107 11


Three novel compounds, 4-methyl-candidusin A (<b>1</b>), aspetritone A (<b>2</b>) and aspetritone B (<b>3</b>), were obtained from the culture of a coral-derived fungus <i>Aspergillus tritici</i> SP2-8-1, together with fifteen known compounds (<b>4</b>-<b>18</b>). Their structures, including absolute configurations, were assigned based on NMR, MS, and time-dependent density functional theory (TD-DFT) ECD calculations. Compounds <b>2</b> and <b>5</b> exhibited better activities against methicilli  ...[more]

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