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Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species.

ABSTRACT: The organic extract of liquid cultures of the marine-derived Penicillium sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A (1) and B (2), together with the previously reported cyclo(R-Pro-S-Phe) (3) and cyclo(R-Pro-R-Phe) (4). The structures of compounds 1-4 were assigned by extensive interpretation of their NMR and high-resolution mass spectrometry (HRMS). The antiproliferative and cytotoxic activities of the compounds against three human cancer cell lines as well as their antimicrobial activity against several pathogens were evaluated. Compounds 2-4 displayed variable cytotoxic and antimicrobial activities.

SUBMITTER: Youssef DTA

PROVIDER: S-EPMC6017105 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species.

Youssef Diaa T A DTA Alahdal Abdulrahman M AM

Molecules (Basel, Switzerland) 20180212 2

The organic extract of liquid cultures of the marine-derived Penicillium sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A (1) and B (2), together with the previously reported cyclo(R-Pro-S-Phe) (3) and cyclo(R-Pro-R-Phe) (4). The structures of compounds 1-4 were assigned by extensive interpretation of their NMR and high-re ...[more]

PMID: 29439550

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