Ontology highlight
ABSTRACT:
SUBMITTER: Ezponda T
PROVIDER: S-EPMC5706555 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ezponda Teresa T Dupéré-Richer Daphné D Will Christine M CM Small Eliza C EC Varghese Nobish N Patel Tej T Nabet Behnam B Popovic Relja R Oyer Jon J Bulic Marinka M Zheng Yupeng Y Huang Xiaoxiao X Shah Mrinal Y MY Maji Sayantan S Riva Alberto A Occhionorelli Manuela M Tonon Giovanni G Kelleher Neil N Keats Jonathan J Licht Jonathan D JD
Cell reports 20171001 3
Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX leads to deactivation of gene expression ultimately promoting the proliferation, clonogenicity, adhesion, and tumorigenicity of MM cells. Moreover, UTX mutant cells showed increased in vitro and in vivo sensitivity to inhibition of EZH2, a histone methyltransferase that generates H3K27me3. Such sensitivity was related ...[more]