Ontology highlight
ABSTRACT:
SUBMITTER: Lang A
PROVIDER: S-EPMC6520694 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Lang Alexander A Yilmaz Merve M Hader Christiane C Murday Sammy S Kunz Xenia X Wagner Nicholas N Wiek Constanze C Petzsch Patrick P Köhrer Karl K Koch Julian J Hoffmann Michéle J MJ Greife Annemarie A Schulz Wolfgang A WA
Cancers 20190404 4
The histone demethylase Ubiquitously Transcribed Tetratricopeptide Repeat Protein X-Linked (UTX/KDM6A) demethylates H3K27me2/3 at genes and enhancers and is often inactivated by mutations in urothelial carcinoma (UC). The consequences of its inactivation are however poorly understood. We have investigated the consequences of moderate UTX overexpression across a range of UC cell lines with or without mutations in <i>KDM6A</i> or its interaction partners and in a normal control cell line. Effects ...[more]