Doxycycline induces dysbiosis in female C57BL/6NCrl mice.
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ABSTRACT:
SUBMITTER: Boynton FDD
PROVIDER: S-EPMC5708113 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Doxycycline induces dysbiosis in female C57BL/6NCrl mice.
Boynton Felicia D Duke FDD Ericsson Aaron C AC Uchihashi Mayu M Dunbar Misha L ML Wilkinson J Erby JE
BMC research notes 20171129 1
<h4>Objective</h4>This study aims to demonstrate the effect of oral doxycycline on fecal microbiota of mice. Doxycycline is a common effector for control of gene expression using the tet-inducible system in transgenic mice. The effect of oral doxycycline on murine gut microbiota has not been reported. We evaluated the effect of doxycycline treatment by sequencing the V4 hypervariable region of the 16S rRNA gene from fecal samples collected during a 4 week course of treatment at a dose of 2 mg/ml ...[more]
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