Doxycycline reduces osteopenia in female rats.

ABSTRACT: Doxycycline, a member of the tetracycline family, is a drug used as an antibiotic (dosage of 100?mg/day) and as an anti-inflammatory drug on the dosage of 20?mg twice a day, this use has Matrix Metalloproteinases (MMP) inhibitor action. Doxycycline is a calcium chelator and therefore interferes in bone remodeling. The main objective of this study was to evaluate the action of the drug doxycycline in the control of osteopenia. Sixty three Wistars rats were divided into 9 groups with n?=?7 each, as follow: the control group with doxycycline 10?mg/kg/day (C10), control with doxycycline 30?mg/kg/day (C30) and control (C), ovariectomized group with doxycycline 10?mg/kg/day (OVX10), ovariectomized with doxycycline 30?mg/kg/day (OVX30), and ovariectomized with water (OVX), sedentary group with 10?mg/kg/day (Se10), sedentary with doxycycline 30?mg/kg/day (Se30), and sedentary group with water (Se). Left femoral bone was used for bone densitometry, right femoral bone for histological analysis. The right tibia was intended for chemical quantifications, the total serum was used for cholesterol and calcium quantification. The length of the left femoral bone was measured after the densitometry analysis. Statistical analysis was performed using multivariate general linear model (ANOVA two factors with Bonferroni adjustment) and the TRAP analysis was subjected to normality test and then were subjected to nonparametric test, both with p?

SUBMITTER: de Figueiredo FAT 

PROVIDER: S-EPMC6814740 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature