Ontology highlight
ABSTRACT:
SUBMITTER: Heckman-Stoddard BM
PROVIDER: S-EPMC5709147 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Diabetologia 20170803 9
Multiple epidemiological studies have documented an association between metformin, used for treatment of type 2 diabetes, and reduced cancer incidence and mortality. Cell line models may not accurately reflect the effects of metformin in the clinical setting. Moreover, findings from animal model studies have been inconsistent, whilst those from more recent epidemiological studies have tempered the overall effect size. The purpose of this review is to examine metformin's chemopreventive potential ...[more]