Ontology highlight
ABSTRACT:
SUBMITTER: Singh N
PROVIDER: S-EPMC5709224 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Current hematologic malignancy reports 20171201 6
<h4>Purpose of review</h4>In this review, we discuss the most recent developments in gene-editing technology and discuss their application to adoptive T cell immunotherapy.<h4>Recent findings</h4>Engineered T cell therapies targeting cancer antigens have demonstrated significant efficacy in specific patient populations. Most impressively, CD19-directed chimeric antigen receptor T cells (CART19) have led to impressive responses in patients with B-cell leukemia and lymphoma. CTL019, or KYMRIAH™ (t ...[more]