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Delivery technologies for T cell gene editing: Applications in cancer immunotherapy.

ABSTRACT: While initial approaches to adoptive T cell therapy relied on the identification and expansion of rare tumour-reactive T cells, genetic engineering has transformed cancer immunotherapy by enabling the modification of primary T cells to increase their therapeutic potential. Specifically, gene editing technologies have been utilized to create T cell populations with improved responses to antigens, lower rates of exhaustion, and potential for use in allogeneic applications. In this review, we provide an overview of T cell therapy gene editing strategies and the delivery technologies utilized to genetically engineer T cells. We also discuss recent investigations and clinical trials that have utilized gene editing to enhance the efficacy of T cells and broaden the application of cancer immunotherapies.

SUBMITTER: Atsavapranee ES

PROVIDER: S-EPMC8099660 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Delivery technologies for T cell gene editing: Applications in cancer immunotherapy.

Atsavapranee Ella S ES Billingsley Margaret M MM Mitchell Michael J MJ

EBioMedicine 20210425

While initial approaches to adoptive T cell therapy relied on the identification and expansion of rare tumour-reactive T cells, genetic engineering has transformed cancer immunotherapy by enabling the modification of primary T cells to increase their therapeutic potential. Specifically, gene editing technologies have been utilized to create T cell populations with improved responses to antigens, lower rates of exhaustion, and potential for use in allogeneic applications. In this review, we provi ...[more]

PMID: 33910123

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