Delivery technologies for T cell gene editing: Applications in cancer immunotherapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Atsavapranee ES
PROVIDER: S-EPMC8099660 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Purpose of reviewIn this review, we discuss the most recent developments in gene-editing technology and discuss their application to adoptive T cell immunotherapy.Recent findingsEngineered T cell therapies targeting cancer antigens have demonstrated significant efficacy in specific patient populations. Most impressively, CD19-directed chimeric antigen receptor T cells (CART19) have led to impressive responses in patients with B-cell leukemia and lymphoma. CTL019, or KYMRIAH™ (tisagenlecleucel), a CD19 CAR T cell product developed by Novartis and the University of Pennsylvania, was recently approved for clinical use by the Food and Drug Administration, representing a landmark in the application of adoptive T cell therapies. As CART19 enters routine clinical use, improving the efficacy of this exciting platform is the next step in broader application. Novel gene-editing technologies like CRISPR-Cas9 allow facile editing of specific genes within the genome, generating a powerful platform to further optimize the activity of engineered T cells.
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